Cargando…

OGT-Mediated KEAP1 Glycosylation Accelerates NRF2 Degradation Leading to High Phosphate-Induced Vascular Calcification in Chronic Kidney Disease

Unraveling the complex regulatory pathways that mediate the effects of phosphate on vascular smooth muscle cells (VSMCs) may provide novel targets and therapies to limit the destructive effects of vascular calcification (VC) in patients with chronic kidney disease (CKD). Our previous studies have hi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Tian-Hua, Du, Yinke, Sheng, Zitong, Li, Yue, Qiu, Xiaobo, Tian, Binyao, Yao, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649800/ https://www.ncbi.nlm.nih.gov/pubmed/33192538 http://dx.doi.org/10.3389/fphys.2020.01092

Ejemplares similares

Blueberry Polyphenol Extracts Enhance the Intestinal Antioxidant Capacity in Weaned Rats by Modulating the Nrf2–Keap1 Signal Pathway
por: Zhao, Fangfang, et al.
Publicado: (2021)

OGT Protein Interaction Network (OGT-PIN): A Curated Database of Experimentally Identified Interaction Proteins of OGT
por: Ma, Junfeng, et al.
Publicado: (2021)

SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway
por: Dong, Lei, et al.
Publicado: (2023)

Arginine Enhances Ovarian Antioxidant Capability via Nrf2/Keap1 Pathway during the Luteal Phase in Ewes
por: Ma, Yan, et al.
Publicado: (2022)

Zinc Inhibits HIF-Prolyl Hydroxylase Inhibitor-Aggravated VSMC Calcification Induced by High Phosphate
por: Nagy, Annamária, et al.
Publicado: (2020)

Chaperone‐mediated autophagy degrades Keap1 and promotes Nrf2‐mediated antioxidative response
por: Zhu, Lin, et al.
Publicado: (2022)

Activation of KEAP1/NRF2/P62 signaling alleviates high phosphate-induced calcification of vascular smooth muscle cells by suppressing reactive oxygen species production
por: Wei, Ran, et al.
Publicado: (2019)

Inorganic phosphate accelerates cardiac myofilament relaxation in response to lengthening
por: Wakefield, Jane I., et al.
Publicado: (2022)

Adipocyte OGT governs diet-induced hyperphagia and obesity
por: Li, Min-Dian, et al.
Publicado: (2018)

MicroRNA-34c Inhibits Osteogenic Differentiation and Valvular Interstitial Cell Calcification via STC1-Mediated JNK Pathway in Calcific Aortic Valve Disease
por: Yang, Lieming, et al.
Publicado: (2020)

The KEAP1–NRF2 System in Cancer
por: Taguchi, Keiko, et al.
Publicado: (2017)

Keap1/Nrf2 Signaling Pathway
por: Sykiotis, Gerasimos P.
Publicado: (2021)

Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes
por: Liu, Jing, et al.
Publicado: (2017)

O-linked N-acetylglucosamine transferase (OGT) is overexpressed and promotes O-linked protein glycosylation in esophageal squamous cell carcinoma
por: Qiao, Zhe, et al.
Publicado: (2012)

Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein
por: Camp, Nathan D., et al.
Publicado: (2012)

OGT Ohio graduation test mathematics
por: Brice, J, et al.
Publicado: (2012)

Structural basis of Keap1 interactions with Nrf2
por: Canning, Peter, et al.
Publicado: (2015)

Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals
por: Bhattacharjee, Shamee, et al.
Publicado: (2020)

The KEAP1/NRF2 Signaling Pathway in Keratinization
por: Ishitsuka, Yosuke, et al.
Publicado: (2020)

The KEAP1-NRF2 System and Esophageal Cancer
por: Hirose, Wataru, et al.
Publicado: (2022)

Modulation of NRF2/KEAP1 Signaling in Preeclampsia
por: Tossetta, Giovanni, et al.
Publicado: (2023)

Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer
por: Tian, Yijun, et al.
Publicado: (2016)

Supramolecular Glycosylation Accelerates Proteolytic Degradation of Peptide Nanofibrils
por: Yuan, Dan, et al.
Publicado: (2015)

Role of Glycosylation in Vascular Calcification
por: Masbuchin, Ainun Nizar, et al.
Publicado: (2021)

HDL functionality is dependent on hepatocyte stress defense factors Nrf1 and Nrf2
por: Trites, Michael J., et al.
Publicado: (2023)

Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice
por: Seedorf, Klaus, et al.
Publicado: (2022)

OGT restrains the expansion of DNA damage signaling
por: Chen, Qiang, et al.
Publicado: (2016)

Every OGT Is Illuminated … by Fluorescent and Synchrotron Lights
por: Miggiano, Riccardo, et al.
Publicado: (2017)

Specificity of oligonucleotide gene therapy (OGT) agents
por: Nedorezova, Daria D., et al.
Publicado: (2022)

Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation
por: Gong, Meiling, et al.
Publicado: (2020)

Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein
por: Chatterjee, Nirmalya, et al.
Publicado: (2016)

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
por: Dinkova-Kostova, Albena T., et al.
Publicado: (2017)

WDR23 regulates NRF2 independently of KEAP1
por: Lo, Jacqueline Y., et al.
Publicado: (2017)

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway
por: Hassanein, Emad H. M., et al.
Publicado: (2020)

Nrf2/Keap1/ARE signaling: Towards specific regulation
por: Ulasov, Alexey V., et al.
Publicado: (2022)

The KEAP1-NRF2 System in Healthy Aging and Longevity
por: Matsumaru, Daisuke, et al.
Publicado: (2021)

Molecular Basis of the KEAP1-NRF2 Signaling Pathway
por: Suzuki, Takafumi, et al.
Publicado: (2023)

Insights into the Regulation of GFR by the Keap1-Nrf2 Pathway
por: Kidokoro, Kengo, et al.
Publicado: (2023)

The role of the Nrf2/Keap1 signaling cascade in mechanobiology and bone health
por: Priddy, Carlie, et al.
Publicado: (2021)

The conserved threonine-rich region of the HCF-1(PRO) repeat activates promiscuous OGT:UDP-GlcNAc glycosylation and proteolysis activities
por: Kapuria, Vaibhav, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_6gchkl6qs72914hafm4p61o790