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Combined subthalamic and nucleus basalis of Meynert deep brain stimulation for Parkinson’s disease with dementia (DEMPARK-DBS): protocol of a randomized, sham-controlled trial

INTRODUCTION: Dementia in Parkinson’s disease (PDD) is a common non-motor symptom of advanced disease, associated with pronounced neocortical cholinergic deficits due to neurodegeneration of the nucleus basalis of Meynert (NBM) and its cholinergic terminals. In advanced PD, patients often require ad...

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Detalles Bibliográficos
Autores principales: Daniels, Christine, Steigerwald, Frank, Capetian, Philipp, Matthies, Cordula, Malzahn, Uwe, Heuschmann, Peter U., Volkmann, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650115/
https://www.ncbi.nlm.nih.gov/pubmed/33324941
http://dx.doi.org/10.1186/s42466-020-00086-w