Systematic Surveys of Iron Homeostasis Mechanisms Reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence

Iron deprivation activates mitophagy and extends lifespan in nematodes. In patients suffering from Parkinson’s disease (PD), PINK1-PRKN mutations via deficient mitophagy trigger iron accumulation and reduce lifespan. To evaluate molecular effects of iron chelator drugs as a potential PD therapy, we...

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Detalles Bibliográficos
Autores principales: Key, Jana, Sen, Nesli Ece, Arsović, Aleksandar, Krämer, Stella, Hülse, Robert, Khan, Natasha Nadeem, Meierhofer, David, Gispert, Suzana, Koepf, Gabriele, Auburger, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650593/
https://www.ncbi.nlm.nih.gov/pubmed/33023155
http://dx.doi.org/10.3390/cells9102229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650593/
https://www.ncbi.nlm.nih.gov/pubmed/33023155
http://dx.doi.org/10.3390/cells9102229

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