Cargando…

Systematic Surveys of Iron Homeostasis Mechanisms Reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence

Iron deprivation activates mitophagy and extends lifespan in nematodes. In patients suffering from Parkinson’s disease (PD), PINK1-PRKN mutations via deficient mitophagy trigger iron accumulation and reduce lifespan. To evaluate molecular effects of iron chelator drugs as a potential PD therapy, we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Key, Jana, Sen, Nesli Ece, Arsović, Aleksandar, Krämer, Stella, Hülse, Robert, Khan, Natasha Nadeem, Meierhofer, David, Gispert, Suzana, Koepf, Gabriele, Auburger, Georg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650593/ https://www.ncbi.nlm.nih.gov/pubmed/33023155 http://dx.doi.org/10.3390/cells9102229

Ejemplares similares

PINK1 and Ataxin-2 as modifiers of growth
por: Sen, Nesli E., et al.
Publicado: (2017)

In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism
por: Sen, Nesli-Ece, et al.
Publicado: (2019)

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes
por: Auburger, Georg, et al.
Publicado: (2019)

Mid-Gestation lethality of Atxn2l-Ablated Mice
por: Key, Jana, et al.
Publicado: (2020)

Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule—Purkinje Neuron Synaptic Strength
por: Arsović, Aleksandar, et al.
Publicado: (2020)

Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis
por: Auburger, Georg, et al.
Publicado: (2016)

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation
por: Torres-Odio, Sylvia, et al.
Publicado: (2017)

The Bacterial ClpXP-ClpB Family Is Enriched with RNA-Binding Protein Complexes
por: Auburger, Georg, et al.
Publicado: (2022)

Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse
por: Maletzko, Antonia, et al.
Publicado: (2021)

Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression
por: Gispert, Suzana, et al.
Publicado: (2015)

Loss of PINK1 Impairs Stress-Induced Autophagy and Cell Survival
por: Parganlija, Dajana, et al.
Publicado: (2014)

Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
por: Gispert, Suzana, et al.
Publicado: (2009)

Self-Assembly in the Ferritin Nano-Cage Protein Superfamily
por: Zhang, Yu, et al.
Publicado: (2011)

Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA
por: Key, Jana, et al.
Publicado: (2021)

CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2
por: Key, Jana, et al.
Publicado: (2022)

Striatal Dopamine Transmission Is Subtly Modified in Human A53Tα-Synuclein Overexpressing Mice
por: Platt, Nicola J., et al.
Publicado: (2012)

Both Ubiquitin Ligases FBXW8 and PARK2 Are Sequestrated into Insolubility by ATXN2 PolyQ Expansions, but Only FBXW8 Expression Is Dysregulated
por: Halbach, Melanie Vanessa, et al.
Publicado: (2015)

Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway
por: Halbach, Melanie Vanessa, et al.
Publicado: (2016)

PINK1-Interacting Proteins: Proteomic Analysis of Overexpressed PINK1
por: Rakovic, Aleksandar, et al.
Publicado: (2011)

Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress
por: Kurz, Alexander, et al.
Publicado: (2010)

Complexin-1 and Foxp1 Expression Changes Are Novel Brain Effects of Alpha-Synuclein Pathology
por: Gispert, Suzana, et al.
Publicado: (2014)

Impaired Photic Entrainment of Spontaneous Locomotor Activity in Mice Overexpressing Human Mutant α-Synuclein
por: Pfeffer, Martina, et al.
Publicado: (2018)

Experimental Induction of Intracranial Aneurysms in Rats: A New Model Utilizing a Genetic Modification within the EDNRA Gene
por: Lampmann, Tim, et al.
Publicado: (2022)

TR-FRET-Based Immunoassay to Measure Ataxin-2 as a Target Engagement Marker in Spinocerebellar Ataxia Type 2
por: Bux, Jessica, et al.
Publicado: (2023)

The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs)
por: Behzadi, Payam, et al.
Publicado: (2022)

Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease
por: Key, Jana, et al.
Publicado: (2020)

A novel mechanism of iron-core formation by Pyrococcus furiosus archaeoferritin, a member of an uncharacterized branch of the ferritin-like superfamily
por: Ebrahimi, Kourosh Honarmand, et al.
Publicado: (2012)

A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP
por: Kurz, Alexander, et al.
Publicado: (2011)

ATXN2-CAG42 Sequesters PABPC1 into Insolubility and Induces FBXW8 in Cerebellum of Old Ataxic Knock-In Mice
por: Damrath, Ewa, et al.
Publicado: (2012)

A Histone-Like Protein of Mycobacteria Possesses Ferritin Superfamily Protein-Like Activity and Protects against DNA Damage by Fenton Reaction
por: Takatsuka, Masaki, et al.
Publicado: (2011)

In Cerebellar Atrophy of 12-Month-Old ATM-Null Mice, Transcriptome Upregulations Concern Most Neurotransmission and Neuropeptide Pathways, While Downregulations Affect Prominently Itpr1, Usp2 and Non-Coding RNA
por: Reichlmeir, Marina, et al.
Publicado: (2023)

Pink Disease
por: Allen, F. M. B.
Publicado: (1933)

Pink Disease
por: Garvin, James M.
Publicado: (1943)

Pink Disease
por: Allen, F. M. B.
Publicado: (1945)

Pink Disease
por: Fullerton, Jane M.
Publicado: (1939)

LRRK2 Expression Is Deregulated in Fibroblasts and Neurons from Parkinson Patients with Mutations in PINK1
por: Azkona, Garikoitz, et al.
Publicado: (2016)

Prospecting for Unannotated Enzymes: Discovery of a 3′,5′-Nucleotide Bisphosphate Phosphatase within the Amidohydrolase Superfamily
por: Cummings, Jennifer A., et al.
Publicado: (2014)

Evaluating methods and protocols of ferritin-based magnetogenetics
por: Hernández-Morales, Miriam, et al.
Publicado: (2021)

The Pink Rim Sign: Location of Pink as an Indicator of Melanoma in Dermoscopic Images
por: Rader, Ryan K., et al.
Publicado: (2014)

The expansin superfamily
por: Sampedro, Javier, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_okf6lbjjfrai655vju2pmjg0t5