VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage

SIMPLE SUMMARY: Dynamic remodeling of chromatin requires epigenetic modifications of histones. DNA damage induced by doxorubicin causes an increase in histone H4K16ac, a marker of local chromatin relaxation. We studied the role that VRK1, a chromatin kinase activated by DNA damage, plays in this ear...

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Detalles Bibliográficos
Autores principales: García-González, Raúl, Morejón-García, Patricia, Campillo-Marcos, Ignacio, Salzano, Marcella, Lazo, Pedro A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650776/
https://www.ncbi.nlm.nih.gov/pubmed/33076429
http://dx.doi.org/10.3390/cancers12102986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650776/
https://www.ncbi.nlm.nih.gov/pubmed/33076429
http://dx.doi.org/10.3390/cancers12102986

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