Blood-Brain Barrier Permeable Chitosan Oligosaccharides Interfere with β-Amyloid Aggregation and Alleviate β-Amyloid Protein Mediated Neurotoxicity and Neuroinflammation in a Dose- and Degree of Polymerization-Dependent Manner

It is proven that β-amyloid (Aβ) aggregates containing cross-β-sheet structures led to oxidative stress, neuroinflammation, and neuronal loss via multiple pathways. Therefore, reduction of Aβ neurotoxicity via inhibiting aggregation of Aβ or dissociating toxic Aβ aggregates into nontoxic forms might...

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Detalles Bibliográficos
Autores principales: Zhu, Limeng, Li, Ruilian, Jiao, Siming, Wei, Jinhua, Yan, Yalu, Wang, Zhuo A., Li, Jianjun, Du, Yuguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650801/
https://www.ncbi.nlm.nih.gov/pubmed/32992800
http://dx.doi.org/10.3390/md18100488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650801/
https://www.ncbi.nlm.nih.gov/pubmed/32992800
http://dx.doi.org/10.3390/md18100488

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