Intranasal GSK2245035, a Toll-like receptor 7 agonist, does not attenuate the allergen-induced asthmatic response in a randomized, double-blind, placebo-controlled experimental medicine study

BACKGROUND: Allergic asthma is a heterogenous disorder predominantly driven by a type 2 inflammatory response to aeroallergens. Therapeutic modulation to rebalance these type 2 responses may offer clinical benefit for allergic respiratory inflammatory diseases, with the potential for disease modific...

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Detalles Bibliográficos
Autores principales: Siddall, Hilary, Quint, Diana, Pandya, Hitesh, Powley, Will, Shabbir, Shaila, Hohlfeld, Jens M., Singh, Dave, Lee, Laurie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652256/
https://www.ncbi.nlm.nih.gov/pubmed/33166307
http://dx.doi.org/10.1371/journal.pone.0240964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652256/
https://www.ncbi.nlm.nih.gov/pubmed/33166307
http://dx.doi.org/10.1371/journal.pone.0240964

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