Sites of vulnerability on ricin B chain revealed through epitope mapping of toxin-neutralizing monoclonal antibodies

Ricin toxin’s B subunit (RTB) is a multifunctional galactose (Gal)-/N-acetylgalactosamine (GalNac)-specific lectin that promotes uptake and intracellular trafficking of ricin’s ribosome-inactivating subunit (RTA) into mammalian cells. Structurally, RTB consists of two globular domains (RTB-D1, RTB-D...

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Detalles Bibliográficos
Autores principales: Vance, David J., Poon, Amanda Y., Mantis, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652295/
https://www.ncbi.nlm.nih.gov/pubmed/33166282
http://dx.doi.org/10.1371/journal.pone.0236538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652295/
https://www.ncbi.nlm.nih.gov/pubmed/33166282
http://dx.doi.org/10.1371/journal.pone.0236538

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