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Improving homology modeling from low-sequence identity templates in Rosetta: A case study in GPCRs
As sequencing methodologies continue to advance, the availability of protein sequences far outpaces the ability of structure determination. Homology modeling is used to bridge this gap but relies on high-identity templates for accurate model building. G-protein coupled receptors (GPCRs) represent a...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652349/ https://www.ncbi.nlm.nih.gov/pubmed/33112852 http://dx.doi.org/10.1371/journal.pcbi.1007597 |