Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouse

In mechanosensory hair cells (HCs) of the ear, the transcriptional repressor REST is continuously inactivated by alternative splicing of its pre-mRNA. This mechanism of REST inactivation is crucial for hearing in humans and mice. Rest is one of many pre-mRNAs whose alternative splicing is regulated...

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Detalles Bibliográficos
Autores principales: Nakano, Yoko, Wiechert, Susan, Fritzsch, Bernd, Bánfi, Botond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652395/
https://www.ncbi.nlm.nih.gov/pubmed/33087486
http://dx.doi.org/10.26508/lsa.202000841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652395/
https://www.ncbi.nlm.nih.gov/pubmed/33087486
http://dx.doi.org/10.26508/lsa.202000841

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