Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

When ribosomes fail to complete normal translation, all cells have mechanisms to ensure degradation of the resulting partial proteins to safeguard proteome integrity. In Escherichia coli and other eubacteria, the tmRNA system rescues stalled ribosomes and adds an ssrA tag or degron to the C-terminus...

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Detalles Bibliográficos
Autores principales: Fei, Xue, Bell, Tristan A, Barkow, Sarah R, Baker, Tania A, Sauer, Robert T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652416/
https://www.ncbi.nlm.nih.gov/pubmed/33089779
http://dx.doi.org/10.7554/eLife.61496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652416/
https://www.ncbi.nlm.nih.gov/pubmed/33089779
http://dx.doi.org/10.7554/eLife.61496

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