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Wwox Deficiency Causes Downregulation of Prosurvival ERK Signaling and Abnormal Homeostatic Responses in Mouse Skin
Deficiency of tumor suppressor WW domain-containing oxidoreductase (WWOX) in humans and animals leads to growth retardation and premature death during postnatal developmental stages. Skin integrity is essential for organism survival due to its protection against dehydration and hypothermia. Our prev...
Autores principales: | Chou, Ying-Tsen, Lai, Feng-Jie, Chang, Nan-Shan, Hsu, Li-Jin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652735/ https://www.ncbi.nlm.nih.gov/pubmed/33195192 http://dx.doi.org/10.3389/fcell.2020.558432 |
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