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Phthalates in the diet of Mexican children of school age. Risk analysis

Phthalates are widely used as plasticizers, additives, or solvents. Its extensive use has generated environmental and food contamination, which implies continuous population exposure. The aim of this work was to determine the probability of health risk of Mexican children exposed to phthalates throu...

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Autores principales: García-Fabila, María Magdalena, Chávez, Araceli Amaya, Meza, Juan Carlos Sánchez, Montes, Lilia Patricia Bustamante, García, Alicia Reyes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652773/
https://www.ncbi.nlm.nih.gov/pubmed/33204649
http://dx.doi.org/10.1016/j.toxrep.2020.10.020
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author García-Fabila, María Magdalena
Chávez, Araceli Amaya
Meza, Juan Carlos Sánchez
Montes, Lilia Patricia Bustamante
García, Alicia Reyes
author_facet García-Fabila, María Magdalena
Chávez, Araceli Amaya
Meza, Juan Carlos Sánchez
Montes, Lilia Patricia Bustamante
García, Alicia Reyes
author_sort García-Fabila, María Magdalena
collection PubMed
description Phthalates are widely used as plasticizers, additives, or solvents. Its extensive use has generated environmental and food contamination, which implies continuous population exposure. The aim of this work was to determine the probability of health risk of Mexican children exposed to phthalates through the consumption of contaminated food. A survey was applied to 384 Mexican school-age children (between 6 and 12 years old), to find out the type of food they eat most frequently, based on this, a research was made to know the concentration of phthalates contained in these foods. The daily intake had been calculated with the concentration of phthalates reported in food, obtaining: DEHP (19.50 μg/kg body weight/day), DnBP (5.52 μg/kg body weight/day) y for DEP (1.12 μg/kg body weight/day). The hazard index (HI) for DEP y DEHP was 0.49 to 42.5 for internal organs damage reported. HI for reproductive health damage due to exposure to DnBT and DEHP was of 0.04 to 5.58, so that there is a high probability that children's health is at risk. Therefore, it is necessary to a quantitative analysis of phthalates in food consumed in Latin American countries and establish the TDI of phthalates especially, to DEHP, which was obtained the higher HI.
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spelling pubmed-76527732020-11-16 Phthalates in the diet of Mexican children of school age. Risk analysis García-Fabila, María Magdalena Chávez, Araceli Amaya Meza, Juan Carlos Sánchez Montes, Lilia Patricia Bustamante García, Alicia Reyes Toxicol Rep Regular Article Phthalates are widely used as plasticizers, additives, or solvents. Its extensive use has generated environmental and food contamination, which implies continuous population exposure. The aim of this work was to determine the probability of health risk of Mexican children exposed to phthalates through the consumption of contaminated food. A survey was applied to 384 Mexican school-age children (between 6 and 12 years old), to find out the type of food they eat most frequently, based on this, a research was made to know the concentration of phthalates contained in these foods. The daily intake had been calculated with the concentration of phthalates reported in food, obtaining: DEHP (19.50 μg/kg body weight/day), DnBP (5.52 μg/kg body weight/day) y for DEP (1.12 μg/kg body weight/day). The hazard index (HI) for DEP y DEHP was 0.49 to 42.5 for internal organs damage reported. HI for reproductive health damage due to exposure to DnBT and DEHP was of 0.04 to 5.58, so that there is a high probability that children's health is at risk. Therefore, it is necessary to a quantitative analysis of phthalates in food consumed in Latin American countries and establish the TDI of phthalates especially, to DEHP, which was obtained the higher HI. Elsevier 2020-10-29 /pmc/articles/PMC7652773/ /pubmed/33204649 http://dx.doi.org/10.1016/j.toxrep.2020.10.020 Text en © 2020 Elsevier B.V. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
García-Fabila, María Magdalena
Chávez, Araceli Amaya
Meza, Juan Carlos Sánchez
Montes, Lilia Patricia Bustamante
García, Alicia Reyes
Phthalates in the diet of Mexican children of school age. Risk analysis
title Phthalates in the diet of Mexican children of school age. Risk analysis
title_full Phthalates in the diet of Mexican children of school age. Risk analysis
title_fullStr Phthalates in the diet of Mexican children of school age. Risk analysis
title_full_unstemmed Phthalates in the diet of Mexican children of school age. Risk analysis
title_short Phthalates in the diet of Mexican children of school age. Risk analysis
title_sort phthalates in the diet of mexican children of school age. risk analysis
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652773/
https://www.ncbi.nlm.nih.gov/pubmed/33204649
http://dx.doi.org/10.1016/j.toxrep.2020.10.020
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