Composite midazolam and 1′-OH midazolam population pharmacokinetic model for constitutive, inhibited and induced CYP3A activity

CYP3A plays an important role in drug metabolism and, thus, can be a considerable liability for drug-drug interactions. Population pharmacokinetics may be an efficient tool for detecting such drug-drug interactions. Multiple models have been developed for midazolam, the typical probe substrate for C...

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Detalles Bibliográficos
Autores principales: Wiebe, Sabrina T., Meid, Andreas D., Mikus, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652802/
https://www.ncbi.nlm.nih.gov/pubmed/32772302
http://dx.doi.org/10.1007/s10928-020-09704-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652802/
https://www.ncbi.nlm.nih.gov/pubmed/32772302
http://dx.doi.org/10.1007/s10928-020-09704-1

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