Retention of antibiotic activity against resistant bacteria harbouring aminoglycoside-N-acetyltransferase enzyme by adjuvants: a combination of in-silico and in-vitro study

Interference with antibiotic activity and its inactivation by bacterial modifying enzymes is a prevailing mode of bacterial resistance to antibiotics. Aminoglycoside antibiotics become inactivated by aminoglycoside-6′-N-acetyltransferase-Ib [AAC(6′)-Ib] of gram-negative bacteria which transfers an a...

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Detalles Bibliográficos
Autores principales: Ahmed, Shamim, Sony, Sabrina Amita, Chowdhury, Md. Belal, Ullah, Md. Mahib, Paul, Shatabdi, Hossain, Tanvir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653040/
https://www.ncbi.nlm.nih.gov/pubmed/33168871
http://dx.doi.org/10.1038/s41598-020-76355-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653040/
https://www.ncbi.nlm.nih.gov/pubmed/33168871
http://dx.doi.org/10.1038/s41598-020-76355-0

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