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Retention of antibiotic activity against resistant bacteria harbouring aminoglycoside-N-acetyltransferase enzyme by adjuvants: a combination of in-silico and in-vitro study

Interference with antibiotic activity and its inactivation by bacterial modifying enzymes is a prevailing mode of bacterial resistance to antibiotics. Aminoglycoside antibiotics become inactivated by aminoglycoside-6′-N-acetyltransferase-Ib [AAC(6′)-Ib] of gram-negative bacteria which transfers an a...

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Detalles Bibliográficos
Autores principales:	Ahmed, Shamim, Sony, Sabrina Amita, Chowdhury, Md. Belal, Ullah, Md. Mahib, Paul, Shatabdi, Hossain, Tanvir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653040/ https://www.ncbi.nlm.nih.gov/pubmed/33168871 http://dx.doi.org/10.1038/s41598-020-76355-0

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