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The influence of base pair tautomerism on single point mutations in aqueous DNA

The relationship between base pair hydrogen bond proton transfer and the rate of spontaneous single point mutations at ambient temperatures and pressures in aqueous DNA is investigated. By using an ensemble-based multiscale computational modelling method, statistically robust rates of proton transfe...

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Detalles Bibliográficos
Autores principales: Gheorghiu, A., Coveney, P. V., Arabi, A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653342/
https://www.ncbi.nlm.nih.gov/pubmed/33178413
http://dx.doi.org/10.1098/rsfs.2019.0120