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Nr4a1 and Nr4a3 Reporter Mice Are Differentially Sensitive to T Cell Receptor Signal Strength and Duration

Nr4a receptors are activated by T cell receptor (TCR) signaling and play key roles in T cell differentiation. Which TCR signaling pathways regulate Nr4a receptors and their sensitivities to TCR signal strength and duration remains unclear. Using Nr4a1/Nur77-GFP and Nr4a3-Timer of cell kinetics and a...

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Detalles Bibliográficos
Autores principales: Jennings, Emma, Elliot, Thomas A.E., Thawait, Natasha, Kanabar, Shivani, Yam-Puc, Juan Carlos, Ono, Masahiro, Toellner, Kai-Michael, Wraith, David C., Anderson, Graham, Bending, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653457/
https://www.ncbi.nlm.nih.gov/pubmed/33147449
http://dx.doi.org/10.1016/j.celrep.2020.108328