TBK1 regulates regeneration of pancreatic β-cells

Small-molecule inhibitors of non-canonical IκB kinases TANK-binding kinase 1 (TBK1) and IκB kinase ε (IKKε) have shown to stimulate β-cell regeneration in multiple species. Here we demonstrate that TBK1 is predominantly expressed in β-cells in mammalian islets. Proteomic and transcriptome analyses r...

Descripción completa

Detalles Bibliográficos
Autores principales: Jia, Yun-Fang, Jeeva, Subbiah, Xu, Jin, Heppelmann, Carrie Jo, Jang, Jin Sung, Slama, Michael Q., Tapadar, Subhasish, Oyelere, Adegboyega K., Kang, Sang-Moo, Matveyenko, Aleksey V., Peterson, Quinn P., Shin, Chong Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653919/
https://www.ncbi.nlm.nih.gov/pubmed/33168920
http://dx.doi.org/10.1038/s41598-020-76600-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653919/
https://www.ncbi.nlm.nih.gov/pubmed/33168920
http://dx.doi.org/10.1038/s41598-020-76600-6

Ejemplares similares