Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury

Aquaporin 3 (AQP3) is a transporter of water, glycerol and hydrogen peroxide (H(2)O(2)) that is expressed in various epithelial cells and in macrophages. Here, we developed an anti-AQP3 monoclonal antibody (mAb) that inhibited AQP3-facilitated H(2)O(2) and glycerol transport, and prevented liver inj...

Descripción completa

Detalles Bibliográficos
Autores principales: Hara-Chikuma, Mariko, Tanaka, Manami, Verkman, Alan S., Yasui, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653938/
https://www.ncbi.nlm.nih.gov/pubmed/33168815
http://dx.doi.org/10.1038/s41467-020-19491-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653938/
https://www.ncbi.nlm.nih.gov/pubmed/33168815
http://dx.doi.org/10.1038/s41467-020-19491-5

Ejemplares similares