Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic model

BACKGROUND: A defining pathological hallmark of the progressive neurodegenerative disorder Alzheimer’s disease (AD) is the accumulation of misfolded tau with abnormal post-translational modifications (PTMs). These include phosphorylation at Threonine 231 (T231) and acetylation at Lysine 274 (K274) a...

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Detalles Bibliográficos
Autores principales: Guha, Sanjib, Fischer, Sarah, Johnson, Gail V. W., Nehrke, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654055/
https://www.ncbi.nlm.nih.gov/pubmed/33168053
http://dx.doi.org/10.1186/s13024-020-00410-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654055/
https://www.ncbi.nlm.nih.gov/pubmed/33168053
http://dx.doi.org/10.1186/s13024-020-00410-7

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