Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms

Abnormal synaptic formation and signaling is one of the key molecular features of autism spectrum disorders (ASD). Cortactin binding protein 2 (CTTNBP2), an ASD-linked gene, is known to regulate the subcellular distribution of synaptic proteins, such as cortactin, thereby controlling dendritic spine...

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Detalles Bibliográficos
Autores principales: Shih, Pu-Yun, Hsieh, Bing-Yuan, Tsai, Ching-Yen, Lo, Chiu-An, Chen, Brian E., Hsueh, Yi-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654188/
https://www.ncbi.nlm.nih.gov/pubmed/33168105
http://dx.doi.org/10.1186/s40478-020-01053-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654188/
https://www.ncbi.nlm.nih.gov/pubmed/33168105
http://dx.doi.org/10.1186/s40478-020-01053-x

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