The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER–Golgi membrane contact sites

In response to cholesterol deprivation, SCAP escorts SREBP transcription factors from the endoplasmic reticulum to the Golgi complex for their proteolytic activation, leading to gene expression for cholesterol synthesis and uptake. Here, we show that in cholesterol-fed cells, ER-localized SCAP inter...

Descripción completa

Detalles Bibliográficos
Autores principales: Wakana, Yuichi, Hayashi, Kaito, Nemoto, Takumi, Watanabe, Chiaki, Taoka, Masato, Angulo-Capel, Jessica, Garcia-Parajo, Maria F., Kumata, Hidetoshi, Umemura, Tomonari, Inoue, Hiroki, Arasaki, Kohei, Campelo, Felix, Tagaya, Mitsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654440/
https://www.ncbi.nlm.nih.gov/pubmed/33156328
http://dx.doi.org/10.1083/jcb.202002150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654440/
https://www.ncbi.nlm.nih.gov/pubmed/33156328
http://dx.doi.org/10.1083/jcb.202002150

Ejemplares similares