Analysis of multicenter clinical trials with very low event rates

INTRODUCTION: In a five-arm randomized clinical trial (RCT) with stratified randomization across 54 sites, we encountered low primary outcome event proportions, resulting in multiple sites with zero events either overall or in one or more study arms. In this paper, we systematically evaluated differ...

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Detalles Bibliográficos
Autores principales: Kim, Jiyu, Troxel, Andrea B., Halpern, Scott D., Volpp, Kevin G., Kahan, Brennan C., Morris, Tim P., Harhay, Michael O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654615/
https://www.ncbi.nlm.nih.gov/pubmed/33168073
http://dx.doi.org/10.1186/s13063-020-04801-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654615/
https://www.ncbi.nlm.nih.gov/pubmed/33168073
http://dx.doi.org/10.1186/s13063-020-04801-5

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