High-resolution structures of multiple 5-HT(3A)R-setron complexes reveal a novel mechanism of competitive inhibition

Serotonin receptors (5-HT(3A)R) play a crucial role in regulating gut movement, and are the principal target of setrons, a class of high-affinity competitive antagonists, used in the management of nausea and vomiting associated with radiation and chemotherapies. Structural insights into setron-bindi...

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Detalles Bibliográficos
Autores principales: Basak, Sandip, Kumar, Arvind, Ramsey, Steven, Gibbs, Eric, Kapoor, Abhijeet, Filizola, Marta, Chakrapani, Sudha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655109/
https://www.ncbi.nlm.nih.gov/pubmed/33063666
http://dx.doi.org/10.7554/eLife.57870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655109/
https://www.ncbi.nlm.nih.gov/pubmed/33063666
http://dx.doi.org/10.7554/eLife.57870

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