Cargando…

Stress-induced p53 drives BAG5 cochaperone expression to control α-synuclein aggregation in Parkinson's disease

Parkinson’s disease (PD) is a common neurodegenerative disorder with the pathological hallmark of α-synuclein aggregation. Dysregulation of α-synuclein homeostasis caused by aging, genetic, and environmental factors underlies the pathogenesis of PD. While chaperones are essential for proteostasis, w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Huan-Yun, Lin, Chin-Hsien, Teng, Shu-Chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655153/ https://www.ncbi.nlm.nih.gov/pubmed/33085644 http://dx.doi.org/10.18632/aging.103998

Ejemplares similares

The BAG-1 cochaperone is a negative regulator of p73-dependent transcription
por: Wang, X-H, et al.
Publicado: (2009)

Models of α-synuclein aggregation in Parkinson’s disease
por: Giráldez-Pérez, Rosa María, et al.
Publicado: (2014)

BAG2 drives chemoresistance of breast cancer by exacerbating mutant p53 aggregate
por: Huang, Xinjian, et al.
Publicado: (2023)

Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease
por: Tatenhorst, Lars, et al.
Publicado: (2016)

Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L
por: Cato, Laura, et al.
Publicado: (2014)

Silica Nanoparticles Promote α-Synuclein Aggregation and Parkinson’s Disease Pathology
por: Yuan, Xin, et al.
Publicado: (2022)

Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
por: Emin, Derya, et al.
Publicado: (2022)

Plasma α-synuclein predicts cognitive decline in Parkinson’s disease
por: Lin, Chin-Hsien, et al.
Publicado: (2017)

Alpha-Synuclein Aggregation in Parkinson's Disease
por: Srinivasan, E., et al.
Publicado: (2021)

The Aggregation of Huntingtin and α-Synuclein
por: Chánez-Cárdenas, María Elena, et al.
Publicado: (2012)

Monitoring α-synuclein aggregation
por: Estaun-Panzano, Juan, et al.
Publicado: (2023)

ER stress response plays an important role in aggregation of α-synuclein
por: Jiang, Peizhou, et al.
Publicado: (2010)

An HSP90 cochaperone Ids2 maintains the stability of mitochondrial DNA and ATP synthase
por: Jiang, Pei-Heng, et al.
Publicado: (2021)

Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease
por: Wang, Zerui, et al.
Publicado: (2020)

Hsp70 Cochaperones HspBP1 and BAG-1M Differentially Regulate Steroid Hormone Receptor Function
por: Knapp, Regina T., et al.
Publicado: (2014)

Catecholamines and Neurodegeneration in Parkinson’s Disease—From Diagnostic Marker to Aggregations of α-Synuclein
por: Sawada, Hideyuki, et al.
Publicado: (2013)

Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models
por: Javed, Hayate, et al.
Publicado: (2019)

Disease-Associated α-Synuclein Aggregates as Biomarkers of Parkinson Disease Clinical Stage
por: Majbour, Nour, et al.
Publicado: (2022)

Dynamics of a model for the degradation mechanism of aggregated α-synuclein in Parkinson's disease
por: Yang, Bojie, et al.
Publicado: (2023)

Anionic Nanoplastic Contaminants Promote Parkinson’s Disease-Associated α-Synuclein Aggregation
por: Liu, Zhiyong, et al.
Publicado: (2023)

Anionic nanoplastic contaminants promote Parkinson’s disease–associated α-synuclein aggregation
por: Liu, Zhiyong, et al.
Publicado: (2023)

Hyperosmotic stress induces cell-dependent aggregation of α-synuclein
por: Fragniere, Alexandra M. C., et al.
Publicado: (2019)

Neuronal Oxidative Stress Promotes α-Synuclein Aggregation In Vivo
por: Won, Seok Joon, et al.
Publicado: (2022)

Silencing of Glucocerebrosidase Gene in Drosophila Enhances the Aggregation of Parkinson's Disease Associated α-Synuclein Mutant A53T and Affects Locomotor Activity
por: Abul Khair, Salema B., et al.
Publicado: (2018)

Nanoparticles With Affinity for α-Synuclein Sequester α-Synuclein to Form Toxic Aggregates in Neurons With Endolysosomal Impairment
por: Jiang, Peizhou, et al.
Publicado: (2021)

Investigating the potential effects of α-synuclein aggregation on susceptibility to chronic stress in a mouse Parkinson’s disease model
por: Alwani, Anna, et al.
Publicado: (2023)

The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia
por: Schulz-Schaeffer, Walter J.
Publicado: (2010)

Acceleration of α-Synuclein Aggregation by Exosomes
por: Grey, Marie, et al.
Publicado: (2015)

Deficient immunoproteasome assembly drives gain of α-synuclein pathology in Parkinson's disease
por: Bi, Mingxia, et al.
Publicado: (2021)

New Roles of Glycosaminoglycans in α-Synuclein Aggregation in a Cellular Model of Parkinson Disease
por: Lehri-Boufala, Sonia, et al.
Publicado: (2015)

Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson's disease
por: Basu, Sambuddha, et al.
Publicado: (2015)

Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson’s disease patients
por: Recasens, Ariadna, et al.
Publicado: (2018)

Inflammatory Responses to Monomeric and Aggregated α-Synuclein in Peripheral Blood of Parkinson Disease Patients
por: Piancone, Federica, et al.
Publicado: (2021)

Mechanisms of enhanced aggregation and fibril formation of Parkinson’s disease-related variants of α-synuclein
por: Ohgita, Takashi, et al.
Publicado: (2022)

Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson’s disease
por: Hideshima, Makoto, et al.
Publicado: (2022)

Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease
por: Bongianni, Matilde, et al.
Publicado: (2022)

Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutation
por: Huang, Yue, et al.
Publicado: (2012)

Inducing α-synuclein compaction: a new strategy for inhibiting α-synuclein aggregation?
por: Pinheiro, Francisca, et al.
Publicado: (2019)

Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization
por: Roostaee, Alireza, et al.
Publicado: (2013)

The oncogenic role of the cochaperone Sgt1
por: Ogi, H, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_i0lqfngq12m0lio1tbe03r572j