Systemic overexpression of C-C motif chemokine ligand 2 promotes metabolic dysregulation and premature death in mice with accelerated aging

Injection of tissues with senescent cells induces changes that mimic aging, and this process is delayed in mice engineered to eliminate senescent cells, which secrete proinflammatory cytokines, including C-C motif chemokine ligand 2 (Ccl2). Circulating levels of Ccl2 correlate with age, but the impa...

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Detalles Bibliográficos
Autores principales: Luciano-Mateo, Fedra, Cabré, Noemí, Baiges-Gaya, Gerard, Fernández-Arroyo, Salvador, Hernández-Aguilera, Anna, Elisabet Rodríguez-Tomàs, Elisabet, Arenas, Meritxell, Camps, Jordi, Menéndez, Javier A., Joven, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655213/
https://www.ncbi.nlm.nih.gov/pubmed/33104522
http://dx.doi.org/10.18632/aging.104154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655213/
https://www.ncbi.nlm.nih.gov/pubmed/33104522
http://dx.doi.org/10.18632/aging.104154

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