Dual inhibition of DNA-PKcs and mTOR by CC-115 potently inhibits human renal cell carcinoma cell growth

CC-115 is a dual inhibitor of DNA-PKcs and mTOR, both are valuable therapeutic targets for renal cell carcinoma (RCC). Our results showed that CC-115 inhibited survival and proliferation of established RCC cell lines (786-O and A489) and primary human RCC cells. The dual inhibitor induced selective...

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Detalles Bibliográficos
Autores principales: Zheng, Bing, Sun, Xu, Chen, Xin-Feng, Chen, Zhan, Zhu, Wei-li, Zhu, Hua, Gu, Dong-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655216/
https://www.ncbi.nlm.nih.gov/pubmed/33109772
http://dx.doi.org/10.18632/aging.103847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655216/
https://www.ncbi.nlm.nih.gov/pubmed/33109772
http://dx.doi.org/10.18632/aging.103847

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