Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability

Extracellular pH has been assumed to play little if any role in how bacteria respond to antibiotics and antibiotic resistance development. Here, we show that the intracellular pH of Escherichia coli equilibrates to the environmental pH following treatment with the DNA damaging antibiotic nalidixic a...

Descripción completa

Detalles Bibliográficos
Autores principales: Booth, James Alexander, Špírek, Mário, Lobie, Tekle Airgecho, Skarstad, Kirsten, Krejci, Lumir, Bjørås, Magnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655802/
https://www.ncbi.nlm.nih.gov/pubmed/33173044
http://dx.doi.org/10.1038/s41598-020-76426-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655802/
https://www.ncbi.nlm.nih.gov/pubmed/33173044
http://dx.doi.org/10.1038/s41598-020-76426-2

Ejemplares similares