Impaired ability of Nef to counteract SERINC5 is associated with reduced plasma viremia in HIV-infected individuals

HIV-1 Nef plays an essential role in enhancing virion infectivity by antagonizing the host restriction molecule SERINC5. Because Nef is highly polymorphic due to the selective forces of host cellular immunity, we hypothesized that certain immune-escape polymorphisms may impair Nef’s ability to antag...

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Detalles Bibliográficos
Autores principales: Toyoda, Mako, Kamori, Doreen, Tan, Toong Seng, Goebuchi, Kageaki, Ohashi, Jun, Carlson, Jonathan, Kawana-Tachikawa, Ai, Gatanaga, Hiroyuki, Oka, Shinichi, Pizzato, Massimo, Ueno, Takamasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656250/
https://www.ncbi.nlm.nih.gov/pubmed/33173092
http://dx.doi.org/10.1038/s41598-020-76375-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656250/
https://www.ncbi.nlm.nih.gov/pubmed/33173092
http://dx.doi.org/10.1038/s41598-020-76375-w

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