Downregulation of Cyp7a1 by Cholic Acid and Chenodeoxycholic Acid in Cyp27a1/ApoE Double Knockout Mice: Differential Cardiovascular Outcome

Sterol 27-hydroxylase (CYP27A1) is a key enzyme in bile acids (BAs) biosynthesis and a regulator of cholesterol metabolism. Cyp27a1/Apolipoprotein E double knockout (DKO) mice fed with western diet (WD) are protected from atherosclerosis via up-regulation of hepatic Cyp7a1 and Cyp3a11. Since feeding...

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Detalles Bibliográficos
Autores principales: Zurkinden, Line, Sviridov, Dmitri, Vogt, Bruno, Escher, Genevieve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656987/
https://www.ncbi.nlm.nih.gov/pubmed/33193099
http://dx.doi.org/10.3389/fendo.2020.586980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656987/
https://www.ncbi.nlm.nih.gov/pubmed/33193099
http://dx.doi.org/10.3389/fendo.2020.586980

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