Cargando…

IL-12-Induced Immune Suppressive Deficit During CD8+ T-Cell Differentiation

Autoimmune diseases are characterized by regulatory deficit in both the CD4+ and CD8+ T-cell compartments. We have shown that CD8+ T-cells associated with acute relapse of multiple sclerosis are significantly deficient in their immune suppressive ability. We hypothesized that distinct CD8+ cytotoxic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Renavikar, Pranav S., Sinha, Sushmita, Brate, Ashley A., Borcherding, Nicholas, Crawford, Michael P., Steward-Tharp, Scott M., Karandikar, Nitin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657266/ https://www.ncbi.nlm.nih.gov/pubmed/33193343 http://dx.doi.org/10.3389/fimmu.2020.568630

Ejemplares similares

Altered expression of SIRPγ on the T-cells of relapsing remitting multiple sclerosis and type 1 diabetes patients could potentiate effector responses from T-cells
por: Sinha, Sushmita, et al.
Publicado: (2020)

Early IFNγ-Mediated and Late Perforin-Mediated Suppression of Pathogenic CD4 T Cell Responses Are Both Required for Inhibition of Demyelinating Disease by CNS-Specific Autoregulatory CD8 T Cells
por: Boyden, Alexander W., et al.
Publicado: (2018)

An autoimmune disease risk SNP, rs2281808, in SIRPG is associated with reduced expression of SIRPγ and heightened effector state in human CD8 T-cells
por: Sinha, Sushmita, et al.
Publicado: (2018)

CD8(+) T-Cells as Immune Regulators of Multiple Sclerosis
por: Sinha, Sushmita, et al.
Publicado: (2015)

Suppression of autoimmune demyelinating disease by preferential stimulation of CNS-specific CD8 T cells using Listeria-encoded neuroantigen
por: Itani, Farah R., et al.
Publicado: (2017)

IL-17 cytokines preferentially act on naïve CD4(+) T cells with the IL-17AF heterodimer inducing the greatest functional changes
por: Crawford, Michael P., et al.
Publicado: (2023)

Therapeutic intervention in relapsing autoimmune demyelinating disease through induction of myelin-specific regulatory CD8 T cell responses
por: Brate, Ashley A., et al.
Publicado: (2019)

IL-12 Signaling Contributes to the Reprogramming of Neonatal CD8(+) T Cells
por: Gutiérrez-Reyna, Darely Y., et al.
Publicado: (2020)

Novel B cell-dependent multiple sclerosis model using extracellular domains of myelin proteolipid protein
por: Boyden, Alexander W., et al.
Publicado: (2020)

An extrafollicular pathway for the generation of effector CD8(+) T cells driven by the proinflammatory cytokine, IL-12
por: Shah, Suhagi, et al.
Publicado: (2015)

Langerin(+) CD8α(+) Dendritic Cells Drive Early CD8(+) T Cell Activation and IL-12 Production During Systemic Bacterial Infection
por: Prendergast, Kelly A., et al.
Publicado: (2018)

Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18
por: Jergović, Mladen, et al.
Publicado: (2019)

Corrigendum: Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18
por: Jergović, Mladen, et al.
Publicado: (2020)

Human CD8(+)CD28(−) T Suppressor Cells Expanded by IL-15 In Vitro Suppress in an Allospecific and Programmed Cell Death Protein 1-Dependent Manner
por: Feng, Fu, et al.
Publicado: (2018)

Autoregulatory CD8 T cells depend on cognate antigen recognition and CD4/CD8 myelin determinants
por: Ortega, Sterling B., et al.
Publicado: (2015)

Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2
por: Tsyklauri, Oksana, et al.
Publicado: (2023)

TNF Blockade Maintains an IL-10(+) Phenotype in Human Effector CD4(+) and CD8(+) T Cells
por: Roberts, Ceri A., et al.
Publicado: (2017)

Human CD4 T Cells From Thymus and Cord Blood Are Convertible Into CD8 T Cells by IL-4
por: Nunes-Cabaço, Helena, et al.
Publicado: (2022)

Suppression of HIV Replication by CD8(+) Regulatory T-Cells in Elite Controllers
por: Lu, Wei, et al.
Publicado: (2016)

CD4+CD25+CD127-Foxp3+ and CD8+CD28- Tregs in Renal Transplant Recipients: Phenotypic Patterns, Association With Immunosuppressive Drugs, and Interaction With Effector CD8+ T Cells and CD19+IL-10+ Bregs
por: Aly, Mostafa G., et al.
Publicado: (2021)

Endometrial Cancer Suppresses CD8+ T Cell-Mediated Cytotoxicity in Postmenopausal Women
por: Patel, Mickey V., et al.
Publicado: (2021)

Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act
por: Kalia, Vandana, et al.
Publicado: (2018)

IL-15 Harnesses Pro-inflammatory Function of TEMRA CD8 in Kidney-Transplant Recipients
por: Tilly, Gaëlle, et al.
Publicado: (2017)

A Low Frequency of IL-17-Producing CD8(+) T-Cells Is Associated With Persistent Immune Activation in People Living With HIV Despite HAART-Induced Viral Suppression
por: Perdomo-Celis, Federico, et al.
Publicado: (2018)

CD8(+) T Cells Are Required For Glatiramer Acetate Therapy in Autoimmune Demyelinating Disease
por: Tyler, Andrew F., et al.
Publicado: (2013)

Incomplete Memories: The Natural Suppression of Tissue-Resident Memory CD8 T Cells in the Lung
por: Reagin, Katie L., et al.
Publicado: (2018)

Combined Photosensitization and Vaccination Enable CD8 T-Cell Immunity and Tumor Suppression Independent of CD4 T-Cell Help
por: Varypataki, Eleni Maria, et al.
Publicado: (2019)

Combining IL-10 and Oncolytic Adenovirus Demonstrates Enhanced Antitumor Efficacy Through CD8(+) T Cells
por: Chen, Duo, et al.
Publicado: (2021)

Delivery of IL-2 to the T Cell Surface Through Phosphatidylserine Permits Robust Expansion of CD8 T Cells
por: MacDonald, Alana, et al.
Publicado: (2021)

Elevated IFNA1 and suppressed IL12p40 associated with persistent hyperinflammation in COVID-19 pneumonia
por: Jeon, Kyeongseok, et al.
Publicado: (2023)

Interleukin-12 (IL-12p70) Promotes Induction of Highly Potent Th1-Like CD4(+)CD25(+) T Regulatory Cells That Inhibit Allograft Rejection in Unmodified Recipients
por: Verma, Nirupama Darshan, et al.
Publicado: (2014)

Neuroantigen-Specific Autoregulatory CD8+ T Cells Inhibit Autoimmune Demyelination through Modulation of Dendritic Cell Function
por: Kashi, Venkatesh P., et al.
Publicado: (2014)

IL-6 Improves the Nitric Oxide-Induced Cytotoxic CD8+ T Cell Dysfunction in Human Chagas Disease
por: Sanmarco, Liliana Maria, et al.
Publicado: (2016)

IL-17RA-Signaling Modulates CD8+ T Cell Survival and Exhaustion During Trypanosoma cruzi Infection
por: Tosello Boari, Jimena, et al.
Publicado: (2018)

Human PD-1(hi)CD8(+) T Cells Are a Cellular Source of IL-21 in Rheumatoid Arthritis
por: Higashioka, Kazuhiko, et al.
Publicado: (2021)

IL-15 promotes self-renewal of progenitor exhausted CD8 T cells during persistent antigenic stimulation
por: Lee, Junghwa, et al.
Publicado: (2023)

Interleukin-17D Promotes Pathogenicity During Infection by Suppressing CD8 T Cell Activity
por: Lee, Younghee, et al.
Publicado: (2019)

Corrigendum: Elevated IFNA1 and suppressed IL12p40 associated with persistent hyperinflammation in COVID-19 pneumonia
por: Jeon, Kyeongseok, et al.
Publicado: (2023)

Discovery of IL-8/CXCL8 (The Story from Frederick)
por: Yoshimura, Teizo
Publicado: (2015)

IL-36β Promotes CD8(+) T Cell Activation and Antitumor Immune Responses by Activating mTORC1
por: Zhao, Xin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1caqe48rggti93jm35rte5rrf6