Applicability of hiPSC-Derived Neuronal Cocultures and Rodent Primary Cortical Cultures for In Vitro Seizure Liability Assessment

Seizures are life-threatening adverse drug reactions which are investigated late in drug development using rodent models. Consequently, if seizures are detected, a lot of time, money and animals have been used. Thus, there is a need for in vitro screening models using human cells to circumvent inter...

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Detalles Bibliográficos
Autores principales: Tukker, Anke M, Wijnolts, Fiona M J, de Groot, Aart, Westerink, Remco H S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Emerging Technologies, Methods, and Models
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657345/
https://www.ncbi.nlm.nih.gov/pubmed/32866265
http://dx.doi.org/10.1093/toxsci/kfaa136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657345/
https://www.ncbi.nlm.nih.gov/pubmed/32866265
http://dx.doi.org/10.1093/toxsci/kfaa136

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