Identification of key features required for efficient S-acylation and plasma membrane targeting of sprouty-2

Sprouty-2 is an important regulator of growth factor signalling and a tumour suppressor protein. The defining feature of this protein is a cysteine-rich domain (CRD) that contains twenty-six cysteine residues and is modified by S-acylation. In this study, we show that the CRD of sprouty-2 is differe...

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Detalles Bibliográficos
Autores principales: Locatelli, Carolina, Lemonidis, Kimon, Salaun, Christine, Tomkinson, Nicholas C. O., Chamberlain, Luke H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657471/
https://www.ncbi.nlm.nih.gov/pubmed/33037124
http://dx.doi.org/10.1242/jcs.249664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657471/
https://www.ncbi.nlm.nih.gov/pubmed/33037124
http://dx.doi.org/10.1242/jcs.249664

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