EZH2 inhibition reduces cartilage loss and functional impairment related to osteoarthritis

Histone methyltransferase EZH2 is upregulated during osteoarthritis (OA), which is the most widespread rheumatic disease worldwide, and a leading cause of disability. This study aimed to assess the impact of EZH2 inhibition on cartilage degradation, inflammation and functional disability. In vitro,...

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Detalles Bibliográficos
Autores principales: Allas, Lyess, Brochard, Sybille, Rochoux, Quitterie, Ribet, Jules, Dujarrier, Cleo, Veyssiere, Alexis, Aury-Landas, Juliette, Grard, Ophélie, Leclercq, Sylvain, Vivien, Denis, Ea, Hang-Korng, Maubert, Eric, Cohen-Solal, Martine, Boumediene, Karim, Agin, Véronique, Baugé, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658239/
https://www.ncbi.nlm.nih.gov/pubmed/33177650
http://dx.doi.org/10.1038/s41598-020-76724-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658239/
https://www.ncbi.nlm.nih.gov/pubmed/33177650
http://dx.doi.org/10.1038/s41598-020-76724-9

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