PD-1 Blockade Reverses Obesity-Mediated T Cell Priming Impairment

Despite obesity reaching pandemic proportions, its impact on antigen-specific T cell responses is still unclear. We have recently demonstrated that obesity results in increased expression of PD-1 on T cells, and checkpoint blockade targeting PD-1/PD-L1 surprisingly resulted in greater clinical effic...

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Detalles Bibliográficos
Autores principales: Le, Catherine T., Khuat, Lam T., Caryotakis, Sofia E., Wang, Marilyn, Dunai, Cordelia, Nguyen, Alan V., Vick, Logan V., Stoffel, Kevin M., Blazar, Bruce R., Monjazeb, Arta M., Murphy, William J., Soulika, Athena M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658608/
https://www.ncbi.nlm.nih.gov/pubmed/33193426
http://dx.doi.org/10.3389/fimmu.2020.590568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658608/
https://www.ncbi.nlm.nih.gov/pubmed/33193426
http://dx.doi.org/10.3389/fimmu.2020.590568

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