Centriole-independent mitotic spindle assembly relies on the PCNT–CDK5RAP2 pericentriolar matrix

Centrosomes, composed of centrioles that recruit a pericentriolar material (PCM) matrix assembled from PCNT and CDK5RAP2, catalyze mitotic spindle assembly. Here, we inhibit centriole formation and/or remove PCNT–CDK5RAP2 in RPE1 cells to address their relative contributions to spindle formation. Wh...

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Detalles Bibliográficos
Autores principales: Watanabe, Sadanori, Meitinger, Franz, Shiau, Andrew K., Oegema, Karen, Desai, Arshad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658699/
https://www.ncbi.nlm.nih.gov/pubmed/33170211
http://dx.doi.org/10.1083/jcb.202006010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658699/
https://www.ncbi.nlm.nih.gov/pubmed/33170211
http://dx.doi.org/10.1083/jcb.202006010

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