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What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?

Intratumor heterogeneity is a feature of cancer that is associated with progression, treatment resistance, and recurrence. However, the mechanisms that allow diverse cancer cell lineages to coexist remain poorly understood. The storage effect is a coexistence mechanism that has been proposed to expl...

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Detalles Bibliográficos
Autores principales: Miller, Anna K., Brown, Joel S., Basanta, David, Huntly, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658723/
https://www.ncbi.nlm.nih.gov/pubmed/32723185
http://dx.doi.org/10.1177/1073274820941968
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author Miller, Anna K.
Brown, Joel S.
Basanta, David
Huntly, Nancy
author_facet Miller, Anna K.
Brown, Joel S.
Basanta, David
Huntly, Nancy
author_sort Miller, Anna K.
collection PubMed
description Intratumor heterogeneity is a feature of cancer that is associated with progression, treatment resistance, and recurrence. However, the mechanisms that allow diverse cancer cell lineages to coexist remain poorly understood. The storage effect is a coexistence mechanism that has been proposed to explain the diversity of a variety of ecological communities, including coral reef fish, plankton, and desert annual plants. Three ingredients are required for there to be a storage effect: (1) temporal variability in the environment, (2) buffered population growth, and (3) species-specific environmental responses. In this article, we argue that these conditions are observed in cancers and that it is likely that the storage effect contributes to intratumor diversity. Data that show the temporal variation within the tumor microenvironment are needed to quantify how cancer cells respond to fluctuations in the tumor microenvironment and what impact this has on interactions among cancer cell types. The presence of a storage effect within a patient’s tumors could have a substantial impact on how we understand and treat cancer.
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spelling pubmed-76587232020-11-20 What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy? Miller, Anna K. Brown, Joel S. Basanta, David Huntly, Nancy Cancer Control Commentary & View Intratumor heterogeneity is a feature of cancer that is associated with progression, treatment resistance, and recurrence. However, the mechanisms that allow diverse cancer cell lineages to coexist remain poorly understood. The storage effect is a coexistence mechanism that has been proposed to explain the diversity of a variety of ecological communities, including coral reef fish, plankton, and desert annual plants. Three ingredients are required for there to be a storage effect: (1) temporal variability in the environment, (2) buffered population growth, and (3) species-specific environmental responses. In this article, we argue that these conditions are observed in cancers and that it is likely that the storage effect contributes to intratumor diversity. Data that show the temporal variation within the tumor microenvironment are needed to quantify how cancer cells respond to fluctuations in the tumor microenvironment and what impact this has on interactions among cancer cell types. The presence of a storage effect within a patient’s tumors could have a substantial impact on how we understand and treat cancer. SAGE Publications 2020-07-29 /pmc/articles/PMC7658723/ /pubmed/32723185 http://dx.doi.org/10.1177/1073274820941968 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Commentary & View
Miller, Anna K.
Brown, Joel S.
Basanta, David
Huntly, Nancy
What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?
title What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?
title_full What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?
title_fullStr What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?
title_full_unstemmed What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?
title_short What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?
title_sort what is the storage effect, why should it occur in cancers, and how can it inform cancer therapy?
topic Commentary & View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658723/
https://www.ncbi.nlm.nih.gov/pubmed/32723185
http://dx.doi.org/10.1177/1073274820941968
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