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Synaptic Protein Degradation Controls Sexually Dimorphic Circuits through Regulation of DCC/UNC-40

Sexually dimorphic circuits underlie behavioral differences between the sexes, yet the molecular mechanisms involved in their formation are poorly understood. We show here that sexually dimorphic connectivity patterns arise in C. elegans through local ubiquitin-mediated protein degradation in select...

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Detalles Bibliográficos
Autores principales: Salzberg, Yehuda, Pechuk, Vladyslava, Gat, Asaf, Setty, Hagar, Sela, Sapir, Oren-Suissa, Meital
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658809/
https://www.ncbi.nlm.nih.gov/pubmed/32857970
http://dx.doi.org/10.1016/j.cub.2020.08.002