Conformational changes in myeloperoxidase induced by ubiquitin and NETs containing free ISG15 from systemic lupus erythematosus patients promote a pro-inflammatory cytokine response in CD4(+) T cells

BACKGROUND: Neutrophil extracellular traps (NETs) from patients with systemic lupus erythematosus (SLE) are characterized by lower ubiquitylation and myeloperoxidase (MPO) as a substrate. The structural and functional effect of such modification and if there are additional post-translational modific...

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Detalles Bibliográficos
Autores principales: Carrillo-Vázquez, Daniel Alberto, Jardón-Valadez, Eduardo, Torres-Ruiz, Jiram, Juárez-Vega, Guillermo, Maravillas-Montero, José Luis, Meza-Sánchez, David Eduardo, Domínguez-López, María Lilia, Varela, Jorge Carlos Alcocer, Gómez-Martín, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659105/
https://www.ncbi.nlm.nih.gov/pubmed/33176801
http://dx.doi.org/10.1186/s12967-020-02604-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659105/
https://www.ncbi.nlm.nih.gov/pubmed/33176801
http://dx.doi.org/10.1186/s12967-020-02604-5

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