The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception

The Sigma-1 receptor (σ1R) has emerged as an interesting pharmacological target because it inhibits analgesia mediated by mu-opioid receptors (MOR), and also facilitates the development of neuropathic pain. Based on these findings, the recent cloning of the Sigma-2 receptor (σ2R) led us to investiga...

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Detalles Bibliográficos
Autores principales: Sánchez-Blázquez, Pilar, Cortés-Montero, Elsa, Rodríguez-Muñoz, María, Merlos, Manuel, Garzón-Niño, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659117/
https://www.ncbi.nlm.nih.gov/pubmed/33176836
http://dx.doi.org/10.1186/s13041-020-00676-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659117/
https://www.ncbi.nlm.nih.gov/pubmed/33176836
http://dx.doi.org/10.1186/s13041-020-00676-4

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