Cargando…

The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception

The Sigma-1 receptor (σ1R) has emerged as an interesting pharmacological target because it inhibits analgesia mediated by mu-opioid receptors (MOR), and also facilitates the development of neuropathic pain. Based on these findings, the recent cloning of the Sigma-2 receptor (σ2R) led us to investiga...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sánchez-Blázquez, Pilar, Cortés-Montero, Elsa, Rodríguez-Muñoz, María, Merlos, Manuel, Garzón-Niño, Javier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659117/ https://www.ncbi.nlm.nih.gov/pubmed/33176836 http://dx.doi.org/10.1186/s13041-020-00676-4

Ejemplares similares

Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor
por: Rodríguez-Muñoz, María, et al.
Publicado: (2018)

Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice
por: Sánchez-Blázquez, Pilar, et al.
Publicado: (2018)

Ligands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels
por: Cortés-Montero, Elsa, et al.
Publicado: (2019)

(α)N-Acetyl β-Endorphin Is an Endogenous Ligand of σ1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for σ2Rs in σ1R Oligomers
por: Garzón-Niño, Javier, et al.
Publicado: (2022)

The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9
por: Sánchez-Blázquez, Pilar, et al.
Publicado: (2017)

Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors
por: Rodríguez-Muñoz, María, et al.
Publicado: (2018)

Calmodulin Supports TRPA1 Channel Association with Opioid Receptors and Glutamate NMDA Receptors in the Nervous Tissue
por: Cortés-Montero, Elsa, et al.
Publicado: (2020)

Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction
por: Rodríguez-Muñoz, María, et al.
Publicado: (2016)

Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids
por: Vidal-Torres, Alba, et al.
Publicado: (2023)

The σ1 Receptor and the HINT1 Protein Control α2δ1 Binding to Glutamate NMDA Receptors: Implications in Neuropathic Pain
por: Rodríguez-Muñoz, María, et al.
Publicado: (2021)

Mu-Opioid Receptors Transiently Activate the Akt-nNOS Pathway to Produce Sustained Potentiation of PKC-Mediated NMDAR-CaMKII Signaling
por: Sánchez-Blázquez, Pilar, et al.
Publicado: (2010)

The σ1 Receptor Engages the Redox-Regulated HINT1 Protein to Bring Opioid Analgesia Under NMDA Receptor Negative Control
por: Rodríguez-Muñoz, María, et al.
Publicado: (2015)

The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: Implications in neurological disorders
por: Rodríguez-Muñoz, María, et al.
Publicado: (2015)

Editorial: Sigma Receptors
por: Aydar, Ebru, et al.
Publicado: (2020)

The Sigma Enigma: A Narrative Review of Sigma Receptors
por: Pergolizzi, Joseph, et al.
Publicado: (2023)

Sigma receptors and neurological disorders
por: Piechal, Agnieszka, et al.
Publicado: (2021)

Sigma-1 receptor and seizures
por: Vavers, Edijs, et al.
Publicado: (2023)

Chronic Ethanol Consumption in Rats Produces Opioid Antinociceptive Tolerance through Inhibition of Mu Opioid Receptor Endocytosis
por: He, Li, et al.
Publicado: (2011)

Blockade of the Sigma-1 Receptor Relieves Cognitive and Emotional Impairments Associated to Chronic Osteoarthritis Pain
por: Carcolé, Mireia, et al.
Publicado: (2019)

EST79232 and EST79376, Two Novel Sigma-1 Receptor Ligands, Exert Neuroprotection on Models of Motoneuron Degeneration
por: Gaja-Capdevila, Núria, et al.
Publicado: (2022)

Blockade of sigma 1 receptors alleviates sensory signs of diabetic neuropathy in rats
por: Paniagua, N., et al.
Publicado: (2016)

Role of Sigma Receptors in Alcohol Addiction
por: Quadir, Sema G., et al.
Publicado: (2019)

Antinociceptive Profile of Levo-tetrahydropalmatine in Acute and Chronic Pain Mice Models: Role of spinal sigma-1 receptor
por: Kang, Dong-Wook, et al.
Publicado: (2016)

Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria
por: Natsvlishvili, Nino, et al.
Publicado: (2015)

Increased PKC activity and altered GSK3β/NMDAR function drive behavior cycling in HINT1-deficient mice: bipolarity or opposing forces
por: Garzón-Niño, Javier, et al.
Publicado: (2017)

The ALS-Related σ1R E102Q Mutant Eludes Ligand Control and Exhibits Anomalous Response to Calcium
por: Rodríguez-Muñoz, María, et al.
Publicado: (2020)

Evidence for the rare decay $\Sigma^+ \to p \mu^+ \mu^-$
por: Aaij, Roel, et al.
Publicado: (2018)

Inhibitory Effects of Sigma-2 Receptor Agonists on T Lymphocyte Activation
por: Iñiguez, Miguel A., et al.
Publicado: (2013)

Evidence for the $\Sigma^+ \to p \mu^+ \mu^−$ decay at LHCb
por: Dettori, Francesco
Publicado: (2019)

Evidence for the rare decay $\Sigma^+ \to p \mu^+ \mu^-$
por: The LHCb Collaboration
Publicado: (2016)

Search for $\Sigma^+ \to p \mu^+ \mu^-$ decays at LHCb
por: Dettori, Francesco
Publicado: (2016)

The Intriguing Sigma-1 and Sigma-2 Receptors and Their Potential Therapeutic Roles 2.0
por: Abate, Carmen, et al.
Publicado: (2023)

Neuroprotective Effects of Sigma 1 Receptor Ligands on Motoneuron Death after Spinal Root Injury in Mice
por: Gaja-Capdevila, Núria, et al.
Publicado: (2021)

The cannabinoid receptor 1 associates with NMDA receptors to produce glutamatergic hypofunction: implications in psychosis and schizophrenia
por: Sánchez-Blázquez, Pilar, et al.
Publicado: (2014)

The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology in rats
por: Gris, Georgia, et al.
Publicado: (2016)

Role of Sigma Receptors in Methamphetamine-Induced Neurotoxicity
por: Kaushal, Nidhi, et al.
Publicado: (2011)

The Sigma-1 Receptor in Cellular Stress Signaling
por: Hayashi, Teruo
Publicado: (2019)

The Emerging Role of Sigma Receptors in Pain Medicine
por: Pergolizzi Jr, Joseph, et al.
Publicado: (2023)

Evidence for the rare decay $\Sigma^+ \to p \mu^+ \mu^-$ at LHCb
por: Dettori, Francesco
Publicado: (2016)

Cocaine Inhibits Dopamine D(2) Receptor Signaling via Sigma-1-D(2) Receptor Heteromers
por: Navarro, Gemma, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_e0uoarup5al7of9lssfbrdk0hm