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Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration
BACKGROUND: Activation of resident microglia accompanies every known form of neurodegeneration, but the involvement of peripheral monocytes that extravasate and rapidly transform into microglia-like macrophages within the central nervous system during degeneration is far less clear. METHODS: Using a...
Autores principales: | Karlen, Sarah J., Miller, Eric B., Wang, Xinlei, Levine, Emily S., Zawadzki, Robert J., Burns, Marie E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659426/ https://www.ncbi.nlm.nih.gov/pubmed/30553275 http://dx.doi.org/10.1186/s12974-018-1365-4 |
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