High-Resolution Respirometry Reveals MPP(+) Mitochondrial Toxicity Mechanism in a Cellular Model of Parkinson’s Disease

MPP(+) is the active metabolite of MPTP, a molecule structurally similar to the herbicide Paraquat, known to injure the dopaminergic neurons of the nigrostriatal system in Parkinson’s disease models. Within the cells, MPP(+) accumulates in mitochondria where it inhibits complex I of the electron tra...

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Detalles Bibliográficos
Autores principales: Risiglione, Pierpaolo, Leggio, Loredana, Cubisino, Salvatore A. M., Reina, Simona, Paternò, Greta, Marchetti, Bianca, Magrì, Andrea, Iraci, Nunzio, Messina, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659480/
https://www.ncbi.nlm.nih.gov/pubmed/33105548
http://dx.doi.org/10.3390/ijms21217809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659480/
https://www.ncbi.nlm.nih.gov/pubmed/33105548
http://dx.doi.org/10.3390/ijms21217809

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