Senescence Inflames the Pancreatic Tumor Microenvironment

Pancreatic adenocarcinomas (PDACs) are scarcely vascularized and thus virtually insensitive to chemotherapy and immunotherapy. In a recent issue of Cell, Lowe and collaborators(1) have demonstrated that senescence induction by MEK plus CDK4/CDK6 inhibitors favors PDAC revascularization coupled to in...

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Detalles Bibliográficos
Autores principales: Petroni, Giulia, Galluzzi, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659541/
https://www.ncbi.nlm.nih.gov/pubmed/33205059
http://dx.doi.org/10.1016/j.xcrm.2020.100020
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author Petroni, Giulia
Galluzzi, Lorenzo
author_facet Petroni, Giulia
Galluzzi, Lorenzo
author_sort Petroni, Giulia
collection PubMed
description Pancreatic adenocarcinomas (PDACs) are scarcely vascularized and thus virtually insensitive to chemotherapy and immunotherapy. In a recent issue of Cell, Lowe and collaborators(1) have demonstrated that senescence induction by MEK plus CDK4/CDK6 inhibitors favors PDAC revascularization coupled to infiltration by therapeutically actionable CD8(+) T cells.
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spelling pubmed-76595412020-11-16 Senescence Inflames the Pancreatic Tumor Microenvironment Petroni, Giulia Galluzzi, Lorenzo Cell Rep Med Preview Pancreatic adenocarcinomas (PDACs) are scarcely vascularized and thus virtually insensitive to chemotherapy and immunotherapy. In a recent issue of Cell, Lowe and collaborators(1) have demonstrated that senescence induction by MEK plus CDK4/CDK6 inhibitors favors PDAC revascularization coupled to infiltration by therapeutically actionable CD8(+) T cells. Elsevier 2020-05-19 /pmc/articles/PMC7659541/ /pubmed/33205059 http://dx.doi.org/10.1016/j.xcrm.2020.100020 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preview
Petroni, Giulia
Galluzzi, Lorenzo
Senescence Inflames the Pancreatic Tumor Microenvironment
title Senescence Inflames the Pancreatic Tumor Microenvironment
title_full Senescence Inflames the Pancreatic Tumor Microenvironment
title_fullStr Senescence Inflames the Pancreatic Tumor Microenvironment
title_full_unstemmed Senescence Inflames the Pancreatic Tumor Microenvironment
title_short Senescence Inflames the Pancreatic Tumor Microenvironment
title_sort senescence inflames the pancreatic tumor microenvironment
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659541/
https://www.ncbi.nlm.nih.gov/pubmed/33205059
http://dx.doi.org/10.1016/j.xcrm.2020.100020
work_keys_str_mv AT petronigiulia senescenceinflamesthepancreatictumormicroenvironment
AT galluzzilorenzo senescenceinflamesthepancreatictumormicroenvironment

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