Benzobicyclo[3.2.1]octene Derivatives as a New Class of Cholinesterase Inhibitors

A library of amine, oxime, ether, epoxy and acyl derivatives of the benzobicyclo[3.2.1]octene were synthesized and evaluated as inhibitors of both human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The majority of the tested compounds exhibited higher selectivity for BChE. Structura...

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Detalles Bibliográficos
Autores principales: Čadež, Tena, Grgičević, Ana, Ahmetović, Ramiza, Barić, Danijela, Hrvat, Nikolina Maček, Kovarik, Zrinka, Škorić, Irena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659976/
https://www.ncbi.nlm.nih.gov/pubmed/33105595
http://dx.doi.org/10.3390/molecules25214872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659976/
https://www.ncbi.nlm.nih.gov/pubmed/33105595
http://dx.doi.org/10.3390/molecules25214872

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