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Benzobicyclo[3.2.1]octene Derivatives as a New Class of Cholinesterase Inhibitors

A library of amine, oxime, ether, epoxy and acyl derivatives of the benzobicyclo[3.2.1]octene were synthesized and evaluated as inhibitors of both human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The majority of the tested compounds exhibited higher selectivity for BChE. Structura...

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Detalles Bibliográficos
Autores principales:	Čadež, Tena, Grgičević, Ana, Ahmetović, Ramiza, Barić, Danijela, Hrvat, Nikolina Maček, Kovarik, Zrinka, Škorić, Irena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659976/ https://www.ncbi.nlm.nih.gov/pubmed/33105595 http://dx.doi.org/10.3390/molecules25214872

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