Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3β Inhibitors with Improved Metabolic Stability

Glycogen synthase kinase-3β (GSK-3β) is a potential target in the field of Alzheimer’s disease drug discovery. We recently reported a new class of 9H-pyrimido[4,5-b]indole-based GSK-3β inhibitors, of which 3-(3-((7-chloro-9H-pyrimido[4,5-b]indol-4-yl)(methyl)amino)piperidin-1-yl)propanenitrile (1) d...

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Detalles Bibliográficos
Autores principales: Andreev, Stanislav, Pantsar, Tatu, El-Gokha, Ahmed, Ansideri, Francesco, Kudolo, Mark, Anton, Débora Bublitz, Sita, Giulia, Romasco, Jenny, Geibel, Christian, Lämmerhofer, Michael, Goettert, Márcia Ines, Tarozzi, Andrea, Laufer, Stefan A., Koch, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659979/
https://www.ncbi.nlm.nih.gov/pubmed/33105671
http://dx.doi.org/10.3390/ijms21217823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659979/
https://www.ncbi.nlm.nih.gov/pubmed/33105671
http://dx.doi.org/10.3390/ijms21217823

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