Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity

Hypoxia is an adverse prognostic feature of solid cancers that may be overcome with hypoxia-activated prodrugs (HAPs). Tirapazamine (TPZ) is a HAP which has undergone extensive clinical evaluation in this context and stimulated development of optimized analogues. However the subcellular localization...

Descripción completa

Detalles Bibliográficos
Autores principales: Guise, Chris P., Abbattista, Maria R., Anderson, Robert F., Li, Dan, Taghipouran, Rana, Tsai, Angela, Lee, Su Jung, Smaill, Jeff B., Denny, William A., Hay, Michael P., Wilson, William R., Hicks, Kevin O., Patterson, Adam V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660101/
https://www.ncbi.nlm.nih.gov/pubmed/33105798
http://dx.doi.org/10.3390/molecules25214888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660101/
https://www.ncbi.nlm.nih.gov/pubmed/33105798
http://dx.doi.org/10.3390/molecules25214888

Ejemplares similares