Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health

BACKGROUND: A lack of genetic data across generations makes transgenerational Mendelian randomization (MR) difficult. We used UK Biobank and a novel proxy gene-by-environment MR to investigate effects of maternal smoking heaviness in pregnancy on offspring health, using participants’ (generation one...

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Detalles Bibliográficos
Autores principales: Yang, Qian, Millard, Louise A C, Davey Smith, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Mendelian Randomization
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660158/
https://www.ncbi.nlm.nih.gov/pubmed/31834381
http://dx.doi.org/10.1093/ije/dyz250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660158/
https://www.ncbi.nlm.nih.gov/pubmed/31834381
http://dx.doi.org/10.1093/ije/dyz250

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